Investigador en Ciencias Médicas "E"
Investigador Nacional Nivel II
allbioexp@yahoo.com
aluna@inger.gob.mx
Perfil del investigador en ResearchGate
  1. Doctorado: Biología Experimental, Universidad Autónoma Metropolitana, Unidad Iztapalapa.
  2. Maestría: Biología Experimental, Universidad Autónoma Metropolitana, Unidad Iztapalapa
  3. Licenciatura: Biología Experimental, Universidad Autónoma Metropolitana.
  1. Mecanismos moleculares del envejecimiento
  2. Estrés oxidante y envejecimiento
  3. Envejecimiento y cáncer
  1. Los mecanismos de la respuesta hormética inducida con tBHQ son regulados por PKC en un modelo de mioblastos de rata de la línea celular L6. Investigadores: Konigsberg Fainstein M, Gómez Quiroz L.E.
  2. Participación de GDF-11 como factor de regeneración muscular en ratas con obesidad sarcopénica asociada al envejecimiento bajo un regimen de ejercicio. Investigadores: Konigsberg Fainstein M., López Díaz-Guerrero N.E., Mena Montes B.
  1. Gavia-García G, Rosas-Trejo MLÁ, García-Mendoza E, Toledo-Pérez R, Königsberg M, Nájera-Medina O, Luna-López A, González-Torres MC.* t-BHQ Protects Against Oxidative Damage and Maintains the Antioxidant Response in Malnourished Rats. DOSE-RESPONSE. 2018;16(3):PMC6156215.
  2. Maciel-Barón LÁ, Morales-Rosales SL, Silva-Palacios A, Rodríguez-Barrera RH, García-Álvarez JA, Luna-López A, Pérez VI, Torres C, Königsberg M.*. The secretory phenotype of senescent astrocytes isolated from Wistar newborn rats changes with anti-inflammatory drugs, but does not have a short-term effect on neuronal mitochondrial potential. BIOGERONTOLOGY. 2018;19(5):415-433.
  3. Enríquez-Cortina C, Bello-Monroy O, Rosales-Cruz P, Souza V, Miranda RU, Toledo-Pérez R, Luna-López A, Simoni-Nieves A, Hernández-Pando R, Gutiérrez-Ruiz MC, Calvisi DF, Marquardt JU, Bucio L, Gomez-Quiroz LE. Cholesterol overload in the liver aggravates oxidative stress-mediated DNA damage and accelerates hepatocarcinogenesis. ONCOTARGET. 2017;8(61):104136-104148.
  4. Barajas-Gómez BA, Rosas-Carrasco O, Morales-Rosalesa SL, Pedraza-Vázquez G, González-Puertos VY, Juárez-Cedillo T, García-Álvarez JA, López-Diazguerrero NE, Damián-Matsumura PD, Königsberg M, Luna-López A. Relationship of inflammatory profile of elderly patients serum and senescence-associated secretory phenotype with human breast cancer cells proliferation: Role of IL6/IL8 ratio. CYTOKINE. 2017;91:13-29.
  5. Maya-López M, Colín-González AL, Aguilera G, Eduarda de Lima M, Colpo-Ceolin A, Rangel-López E, Villeda-Hernández J, Rembao-Bojórquez D, Túnez I, Luna-López A, Lazzarini-Lechuga R, González-Puertos VY, Posadas-Rodríguez P, Silva-Palacios A, Königsberg M, Santamaría A. Neuroprotective effect of WIN55,212-2 against 3-nitropropionic acid-induced toxicity in the rat brain: involvement of CB1 and NMDA receptors. AM J TRANSL RES. 2017;9(2):261-274.
  6. Silva-Palacios A, Colín-González AL, López-Cervantes SP, Zazuetac C, Luna-López A, Santamaría A, Königsberg M. Tert-buthylhydroquinone pre-conditioning exerts dual effects in old female rats exposed to 3-nitropropionic acid. REDOX BIOL. 2017;12:610-624.
  7. Silva-Palacios A, Ostolga-Chavarría M, Buelna-Chontal M, Garibay C, Hernández-Reséndiz S, Roldán FJ, Flores PL, Luna-López A, Königsberg M, Zazueta C. 3-NP-induced Huntington's-like disease impairs Nrf2 activation without loss of cardiac function in aged rats. EXP GERONTOL. 2017;96:89-98.
  8. Maciel-Barón LA, Morales-Rosales SL, Aquino-Cruz AA, Triana-Martínez F, Galván-Arzate S, Luna-López A, González-Puertos VY, López-Díazguerrero NE, Torres C, Königsberg M. Senescence associated secretory phenotype profile from primary lung mice fibroblasts depends on the senescence induction stimuli. AGE. 2016;38(1):26.
  9. Domínguez-Pérez M, Nuño-Lámbarri N, Clavijo-Cornejo D, Luna-López A, Souza V, Bucio L, Miranda RU, Muñoz L, Gomez-Quiroz LE, Uribe-Carvajal S, Gutiérrez-Ruiz MC. Hepatocyte growth factor reduces free cholesterol-mediated lipotoxicity in primary hepatocytes by countering oxidative stress. OXID MED CELL LONGEV. 2016;7960386:8.
  10. Trejo-Vargasa A, Hernández-Mercado E, Ordóñez-Razo RM, Lazzarini R, Arenas-Aranda DJ, Gutiérrez-Ruiz MC, Königsberg M, Luna-López A. Bik subcellular localization in response to oxidative stress induced by chemotherapy, in Two different breast cancer cell lines and a Non-tumorigenic epithelial cell line. J APPL TOXICOL. 2015;35(11):1262–1270.
  11. Gavia-García G, González-Martínez H, Miliar-García Á, Bonilla González E, Rosas-Trejo MA, Königsber M, Nájera-Medina O, Luna-López A, González-Torres MC. Oxidative damage and antioxidant defense in thymus of malnourished lactating rats. Nutrition. 2015;31(11-12):1408–1415.
  12. Alarcón-Aguilar A, González-Puertos VY, Luna-López A, López-Macay A, Morán J, Santamaría A, Königsberg M. Comparing the effects of two neurotoxins in cortical astrocytes obtained fron rats of different ages: involvement of oxidative damage. J Appl Toxicol. 2014;34(2):127-138.
  13. Colín-González AL, Luna-López A, Königsberg M, Ali SF, Pedraza-Chaverrí J, Santamaría A. Early modulation of the transcription factor Nrf2 in rodent striatal slices by quinolinic acid, a toxic metabolite of the kynurenine pathway. Neuroscience. 2014;260:130–139.
  14. Alarcón-Aguilar A, Luna-López A, Ventura-Gallegos JL, Lazzarini R, Galván-Arzate S, González-Puertos VY, Morán J, Santamaría A, Königsberg M. Primary cultured astrocytes from old rats are capable to activate the Nrf2 response against MPP+ toxicity after tBHQ pretreatment. Neurobiol Aging. 2014;35(8):1901-12.
  15. Luna-López A, González-Puertos VY, López-Diazguerrero NE, Königsberg M. New considerations on hormetic response against oxidative stress. J Cell Commun Signal. 2014;8(4):323-331.
  16. Jiménez-Salazar JE, Posadas-Rodríguez P, Lazzarini-Lechuga RC, Luna-López A, Zentella-Dehesa A, Gómez-Quiroz LE, Königsberg M, Domínguez-Gómez G, Damián-Matsumura P. Membrane-Initiated Estradiol Signaling of Epithelial-Mesenchymal Transition-Associated Mechanisms Through Regulation of Tight Junctions in Human Breast Cancer Cells. Horm Cancer. 2014;5(3):161-73.
  17. Luna-López A, González-Puertos VY, Romero-Ontiveros J, Ventura-Gallegos JL, Zentella A, Gomez-Quiroz LE, Königsberg M. A noncanonical NF-κB pathway through the p50 subunit regulates Bcl-2 overexpression during an oxidative-conditioning hormesis response. Free Radic Biol Med. (FREE RADICAL BIO MED). 2013;3;63C:41-50.
  18. López-Diaz guerrero NE, González Puertos VY, Hernández-Bautista RJ, Alarcón A, Luna-López A, Königsberg Fainstein M. Hormesis: lo que no mata, fortalece. Gaceta Médica de México (GAC MED MEX). 2013;149:438-47.
  19. Conde-Pérezprina JC, Luna-López A, González-Puertos VY, Zenteno-Savín T, León-Galván MA, Königsberg M. DNA MMR systems, microsatellite instability and antioxidant activity variations in two species of wild bats: Myotis velifer and Desmodus rotundus, as possible factors associated with longevity. Age. 2012;34(6):1473-1492.
  20. López-Diazguerrero NE, Pérez-Figueroa GE, Martínez-Garduño CM, Alarcón-Aguilar A, Luna-López A, Gutiérrez-Ruiz MC, Königsberg M. Telomerase activity in response to mild oxidative stress. Cell Biol Int.. 2012;36:409-413.
  21. Luna-López A, Tasset I, Pérez-De La Cruz V, Elinos-Calderón D, Carrillo-Andrade P, Konigsberg M, Pedraza-Chaverrí J, Maldonado PD, Ali SF, Túnez I, Santamaría A. Protective Effect of Tert-Butylhidroquinone on the Quinolinic Acid-Induced Toxicity in Rat Striatal Slices: Role of the NRF2-ARE Pathway Neurosignals 2010;18(1):24-31
  22. Luna-López A, Triana-Martínez F, López-Diazguerrero NE, Ventura-Gallegos JL, Gutiérrez-Ruiz MC, Damián-Matsumura P, Zentella A, Gómez-Quiroz LE, Königsberg M. Bcl-2 sustains hormetic response by inducing Nrf-2 nuclear translocation in L929 mouse fibroblasts. Free radical biology and medicine 2010;49(7):1192-204.